Transient improvement of pyruvate metabolism after coenzyme Q therapy in Kearns-Sayre syndrome: MRS study.

Abstract

Coenzyme Q therapy has been used to support metabolic derangements in patients with mitochondrial encephalomyopathies. Biochemical analysis of the living human brain can be performed by magnetic resonance spectroscopy (MRS). We report upon a KSS patient who was serially imaged with localized proton MRS to monitor the efficacy of CoQ treatment. A 17-year-old girl with KSS was serially imaged with localized proton MRS performed on a GE 1.5 T SIGNA MRI/MRS system. The elevated lactate contents of lesions decreased after one month of CoQ therapy but were re-elevated 10 months after treatment. We conclude that MRS presents us with a powerful tool for monitoring the effects of therapeutic trials in mitochondrial encephalomyopathies.

• Authors: C Choi, I N Sunwoo, H S Kim, D I Kim
• Journal: Yonsei medical journal (Yonsei Med J) Vol. 41 Issue 5 Pg. 676-9 (Oct 2000) ISSN: 0513-5796 [Print] Korea (South)
• PMID: 11079632 (Publication Type: Case Reports, Journal Article)

Chemical References

• Ubiquinone
• Lactic Acid
• Pyruvic Acid

Topics

• Adolescent
• Brain (drug effects, metabolism)
• Female
• Humans
• Kearns-Sayre Syndrome (diagnosis, drug therapy, metabolism)
• Lactic Acid (metabolism)
• Magnetic Resonance Spectroscopy
• Pyruvic Acid (metabolism)
• Treatment Outcome
• Ubiquinone (therapeutic use)