Involvement of 5-hydroxytryptamine(1A) receptors in nicotine-induced tail tremor in rats.

Abstract

Involvement of the serotonergic system in tail tremor induced by repeated administration of nicotine was investigated in rats. Tail tremor induced by nicotine (0.5 mg/kg, s.c.) was suppressed by a 5-HT(1A) receptor antagonist, N-¿2-[4-(2-methoxyphenyl)-1-piperazinyl-]ethyl¿-N-(2-pyridinyl)cycloh exanecarboxamide trihydrochloride (WAY-100635; 0.3-3 mg/kg, i.p.), but not by a 5-HT(2) receptor antagonist, ketanserin (0.1-0.3 mg/kg, i.p). The 5-HT(1A) receptor agonists, buspirone (1-20 mg/kg, i.p.), gepirone (1-10 mg/kg, i.p.), tandospirone (1-10 mg/kg, i.p.) and (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 0.01-0.1 mg/kg, s.c.), enhanced the tail tremor. The enhancement of tail tremor by buspirone (10 mg/kg, i.p.) was blocked by WAY-100635 (0.3-3 mg/kg, i.p.). These findings suggest that nicotine-induced tail tremor is mediated by 5-HT(1A) receptors and that 5-HT(1A) receptor antagonists are effective in the treatment of tremor.

• Authors: K Suemaru, H Araki, Y Gomita
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 408 Issue 1 Pg. 19-23 (Nov 10 2000) ISSN: 0014-2999 [Print] Netherlands
• PMID: 11070179 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nicotinic Agonists
• Receptors, Serotonin
• Receptors, Serotonin, 5-HT1
• Serotonin Antagonists
• Serotonin Receptor Agonists
• Nicotine

Topics

• Animals
• Dose-Response Relationship, Drug
• Injections, Subcutaneous
• Male
• Nicotine (administration & dosage, pharmacology)
• Nicotinic Agonists (administration & dosage, pharmacology)
• Rats
• Rats, Wistar
• Receptors, Serotonin (drug effects)
• Receptors, Serotonin, 5-HT1
• Serotonin Antagonists (pharmacology)
• Serotonin Receptor Agonists (pharmacology)
• Tail (physiology)
• Tremor (chemically induced)