[Interaction between warfarin and oral miconazole gel].

Abstract

We report a case of a 76 year-old woman who had been taking warfarin for seven years because of relapsing deep venous thrombosis. Her daily maintenance dose was 5 mg. Monthly measurements of international normalised ratio (INR) were stable between 2-3. She developed oral candidiasis and miconazole gel was prescribed. One week later she developed bleeding gums. Eight days later she was admitted to the hospital with haematuria. INR was > 10. Warfarin and the miconazole gel were withdrawn. She was treated with phytonadione. INR normalised after four days and she continued warfarin treatment. Caution should be exercised whenever the combination of warfarin and miconazole gel are prescribed.

• Authors: C G Ogard, H Vestergaard
• Journal: Ugeskrift for laeger (Ugeskr Laeger) Vol. 162 Issue 41 Pg. 5511 (Oct 09 2000) ISSN: 0041-5782 [Print] Denmark
• Vernacular Title: Interaktion mellem warfarin og oral miconazol-gel.
• PMID: 11068529 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anticoagulants
• Antifungal Agents
• Warfarin
• Miconazole

Topics

• Aged
• Anticoagulants (administration & dosage, adverse effects, pharmacokinetics)
• Antifungal Agents (administration & dosage, adverse effects)
• Candidiasis, Oral (drug therapy)
• Drug Interactions
• Female
• Humans
• Miconazole (administration & dosage, adverse effects)
• Venous Thrombosis (drug therapy)
• Warfarin (administration & dosage, adverse effects, pharmacokinetics)