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Human cortactin as putative cancer antigen.

Abstract
Humoral immune response against overexpressed oncogenic or tumor supressor proteins has been demonstrated for many types of cancer. In this study we report on the detection of the autologous antibody response to putative oncogene, human cortactin using serological analysis of breast carcinoma expression library. Cortactin maps to chromosome 11q13, the region amplified in about 15% of primary breast carcinomas and 30% of head and neck squamous cell carcinomas. Cortactin overexpression due to such amplification might affect adhesive properties of human cancer cells and is associated with poor disease prognosis. Accordingly, we detected overexpression of cortactin transcript in autologous tumor and amplification/overexpression of cortactin in tumors of breast cancer patients serologically positive for this marker. We demonstrate that 15% of breast cancer patients elicit humoral immune response against human cortactin.
AuthorsM A Lagarkova, V E Boitchenko, A A Mescheryakov, U A Kashkarova, S A Nedospasov
JournalOncogene (Oncogene) Vol. 19 Issue 45 Pg. 5204-7 (Oct 26 2000) ISSN: 0950-9232 [Print] England
PMID11064458 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Neoplasm
  • Antigens, Neoplasm
  • CTTN protein, human
  • Cortactin
  • Microfilament Proteins
Topics
  • Amino Acid Sequence
  • Antibodies, Neoplasm (blood)
  • Antigens, Neoplasm (genetics, immunology)
  • Bacteriophage lambda (genetics)
  • Base Sequence
  • Breast Neoplasms (genetics, immunology)
  • Carcinoma (genetics)
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11
  • Cortactin
  • Female
  • Gene Library
  • Humans
  • Microfilament Proteins (genetics, immunology)
  • Middle Aged
  • Molecular Sequence Data

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