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Hereditary motor and sensory neuropathy--Lom (HMSNL): refined genetic mapping in Romani (Gypsy) families from several European countries.

Abstract
Hereditary motor and sensory neuropathy type Lom, initially identified in Roma (Gypsy) families from Bulgaria, has been mapped to 8q24. Further refined mapping of the region has been undertaken on DNA from patients diagnosed across Europe. The refined map consists of 25 microsatellite markers over approximately 3 cM. In this collaborative study we have identified a number of historical recombinations resulting from the spread of the hereditary motor and sensory neuropathy type Lom gene through Europe with the migration and isolation of Gypsy groups. Recombination mapping and the minimal region of homozygosity reduced the original 3 cM hereditary motor and sensory neuropathy type Lom region to a critical interval of about 200 kb.
AuthorsD Chandler, D Angelicheva, L Heather, R Gooding, D Gresham, P Yanakiev, R de Jonge, F Baas, D Dye, L Karagyozov, A Savov, K Blechschmidt, B Keats, P K Thomas, R H King, A Starr, A Nikolova, J Colomer, B Ishpekova, I Tournev, J A Urtizberea, L Merlini, D Butinar, B Chabrol, T Voit, M Baethmann, V Nedkova, A Corches, L Kalaydjieva
JournalNeuromuscular disorders : NMD (Neuromuscul Disord) Vol. 10 Issue 8 Pg. 584-91 (Dec 2000) ISSN: 0960-8966 [Print] England
PMID11053686 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Adolescent
  • Adult
  • Child
  • Chromosome Mapping
  • DNA Mutational Analysis
  • Disease Progression
  • Europe
  • Female
  • Genotype
  • Haplotypes (genetics)
  • Hereditary Sensory and Motor Neuropathy (genetics)
  • Humans
  • Male
  • Middle Aged
  • Pedigree
  • Phenotype
  • Roma (genetics)

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