HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A controlled clinical trial of chlormezanone, orphenadrine, orphenadrine/paracetamol and placebo in the treatment of painful skeletal muscle spasms.

Abstract
Four hundred patients with painful muscle spasm caused by five common musculoskeletal diseases were included in a double-blind controlled trial of chlormezanone, orphenadrine, orphenadrine/paracetomol and placebo. Patients were treated for one week and then asked for their subjective assessment of the treatment. Fifty-three per cent improved on placebo, 57 percent on chlormezanone, 66 percent on orphenadrine and 71 percent on orphenadrine/paracetamol. There was no significant difference between chlormezanone and placebo, but orphenadrine appeared to have a beneficial effect, presumably because of its muscle relaxant activity.
AuthorsE J Valtonen
JournalAnnals of clinical research (Ann Clin Res) Vol. 7 Issue 2 Pg. 85-8 (Apr 1975) ISSN: 0003-4762 [Print] Finland
PMID1103709 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Placebos
  • Acetaminophen
  • Orphenadrine
  • Chlormezanone
Topics
  • Acetaminophen (therapeutic use)
  • Chlormezanone (therapeutic use)
  • Clinical Trials as Topic
  • Drug Evaluation
  • Drug Therapy, Combination
  • Humans
  • Muscle Cramp (drug therapy)
  • Orphenadrine (therapeutic use)
  • Placebos

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: