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Comparison of two enteric coated microsphere preparations in the treatment of pancreatic exocrine insufficiency caused by cystic fibrosis.

AbstractBACKGROUND:
Pancreatic exocrine insufficiency is a common condition in patients with cystic fibrosis. Large amounts of pancreatic enzyme supplements are required to reduce malabsorption but patient compliance is not always optimal.
AIMS:
To compare patients' preference and the efficacy of two enteric coated microsphere preparations in patients with cystic fibrosis.
PATIENTS:
Patients with pancreatic exocrine insufficiency due to cystic fibrosis.
METHODS:
Patients were assigned to the crossover treatment with Creon or Pancrease for 1 week and then to the alternative treatment. Patients had to follow a fixed diet (at least 2 g fat/kg) and had to assume 1000 units lipase/g fat. The evaluation parameters were: patients' preference, acceptance of therapy, stool fat excretion, stool weight, gastrointestinal symptoms, and tolerance.
RESULTS AND CONCLUSIONS:
Of the 33/60 patients who expressed a preference for one of the two treatments, 30 preferred Creon while only 3 patients preferred Pancrease (p<0.001). No difference between the two treatments was observed regarding stool characteristics, gastrointestinal symptoms and tolerance. The mean number of capsules taken daily was reduced by 35% with Creon. The results of this study showed a preference in favour of Creon probably due to the reduction of daily capsule intake of 35%, supporting digestion as well as Pancrease.
AuthorsB Santini, M Antonelli, A Battistini, S Bertasi, M Collura, I Esposito, L Di Febbraro, R Ferrari, L Ferrero, L Iapichino, V Lucidi, A Manca, C L Pisconti, G Pisi, V Raia, L Romano, P Rosati, I Grazioli, G Melzi
JournalDigestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver (Dig Liver Dis) 2000 Jun-Jul Vol. 32 Issue 5 Pg. 406-11 ISSN: 1590-8658 [Print] Netherlands
PMID11030186 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References
  • Capsules
  • Gastrointestinal Agents
  • Pancrelipase
  • Lipase
  • Amylases
  • Endopeptidases
Topics
  • Adolescent
  • Adult
  • Amylases (administration & dosage)
  • Capsules
  • Child
  • Cystic Fibrosis (complications)
  • Drug Tolerance
  • Endopeptidases (administration & dosage)
  • Exocrine Pancreatic Insufficiency (drug therapy, etiology)
  • Female
  • Gastrointestinal Agents (administration & dosage)
  • Humans
  • Lipase (administration & dosage)
  • Male
  • Microspheres
  • Pancrelipase (administration & dosage)
  • Patient Acceptance of Health Care
  • Safety

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