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Clinical trial with Secnidazole in a single dose in Venezuelan children infected by Giardia intestinalis.

Abstract
The aim of this work was to evaluate in an open, noncomparative study the use of secnidazole in oral suspension given to Venezuelan children infected with Giardia intestinalis, from a community in Carapita, a slum area in Caracas. Seventy children from 2 to 11 years old (38 males and 32 females) were treated with a single oral dose of secnidazole (30 mg/Kg of body weight), after clinical and parasitological evaluation to make the diagnosis of active giardiasis. The effectiveness of treatment was determined by clinical examination and parasitological evaluation of feces samples 15 days after treatment. The results showed 95% of clinical cure with a significant decrease of the frequency of gastrointestinal symptoms. The parasitological cure was 98%, there were 4 failures at the end of treatment. Side effects observed after treatment were of mild intensity, lasting only few hours. These results show that a simple dose of secnidazole in an oral suspension is an effective, safe and well tolerated treatment for giardiasis in children and that this drug may be used as a mass treatment in risk populations.
AuthorsM C Di Prisco, J C Jiménez, N Rodríguez, V Costa, J Villamizar, A Silvera, M Carrillo, C Lira, E Zerpa, Y López
JournalInvestigacion clinica (Invest Clin) Vol. 41 Issue 3 Pg. 179-88 (Sep 2000) ISSN: 0535-5133 [Print] Venezuela
PMID11029834 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antiprotozoal Agents
  • Metronidazole
  • secnidazole
Topics
  • Administration, Oral
  • Animals
  • Antiprotozoal Agents (administration & dosage, adverse effects)
  • Child
  • Child, Preschool
  • Data Interpretation, Statistical
  • Female
  • Giardiasis (diagnosis, drug therapy)
  • Humans
  • Male
  • Metronidazole (administration & dosage, adverse effects, analogs & derivatives)
  • Poverty Areas
  • Risk Factors
  • Socioeconomic Factors
  • Venezuela

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