Solitary fibrous tumors are immunophenotypically distinct from mesothelioma(s).

Abstract

INTRODUCTION:

Solitary fibrous tumor is a soft tissue tissue tumor of unknown histogenesis. Based upon histologic similarities and CD-34 expression, it has been suggested that these neoplasms bear some relationship to mesothelioma, and may represent its extra-pleural equivalent.

METHODS:

In order to further investigate this possible relationship, we examined a series of five dermal and five extra-cutaneous solitary fibrous tumors with antibodies directed against the mesothelial markers calretinin and HBME-1.

RESULTS:

All the lesions failed to stain with the antibodies tested. This suggests that despite some similar histologic and immunophenotypic features, these lesions are not immunophenotypically identical. Mesotheliomas are CD-34(+), calretinin(+), HBME-1(+), while solitary fibrous tumors are CD-34(+), calretinin(-), HBME-1(-).

CONCLUSIONS:

The histogenesis of solitary fibrous tumor remains elusive. It is unlikely that tumor location or tumor de-differentiation accounts for the dichotomous staining properties, as these neoplasms show a similarly benign histologic appearance regardless of location.

• Authors: M B Morgan, B R Smoller
• Journal: Journal of cutaneous pathology (J Cutan Pathol) Vol. 27 Issue 9 Pg. 451-4 (Oct 2000) ISSN: 0303-6987 [Print] United States
• PMID: 11028815 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antigens, CD34
• Biomarkers, Tumor
• CALB2 protein, human
• Calbindin 2
• Neoplasm Proteins
• S100 Calcium Binding Protein G

Topics

• Adult
• Aged
• Antigens, CD34 (analysis)
• Biomarkers, Tumor (analysis)
• Calbindin 2
• Female
• Fibroma (chemistry, pathology)
• Humans
• Immunoenzyme Techniques
• Immunophenotyping
• Male
• Mesothelioma (chemistry, pathology)
• Middle Aged
• Neoplasm Proteins (analysis)
• Orbital Neoplasms (chemistry, pathology)
• Respiratory Tract Neoplasms (chemistry, pathology)
• S100 Calcium Binding Protein G (analysis)
• Skin Neoplasms (chemistry, pathology)