Cerebral vasculopathy and multiple infarctions in a woman with carcinomatous meningitis while on treatment with intrathecal methotrexate.

Abstract	We report on a 33-year-old woman with carcinomatous meningitis due to carcinoma of the breast who developed multiple cerebral infarctions within four days after intrathecal chemotherapy with methotrexate. MR angiography revealed a narrowing of basal cerebral arteries, which is consistent with vasculopathy. The vasculopathy was probably due to carcinomatous meningitis itself, an acute toxic effect of methotrexate, or a combination of both.
Authors	S Kastenbauer, M Wiesmann, H W Pfister
Journal	Journal of neuro-oncology (J Neurooncol) Vol. 48 Issue 1 Pg. 41-5 (May 2000) ISSN: 0167-594X [Print] United States
PMID	11026695 (Publication Type: Case Reports, Journal Article)
Chemical References	Antimetabolites, Antineoplastic Methotrexate
Topics	Adult Antimetabolites, Antineoplastic (adverse effects) Carotid Stenosis (chemically induced, pathology) Fatal Outcome Female Humans Infarction, Anterior Cerebral Artery (chemically induced, pathology) Infarction, Middle Cerebral Artery (chemically induced, pathology) Injections, Spinal Magnetic Resonance Angiography Meningeal Neoplasms (complications, drug therapy) Meningitis (etiology) Methotrexate (adverse effects)

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