Abstract | BACKGROUND: METHODS: A nonrandomized crossover cohort study involving 54 patients with multi-organ failure (of whom 19 had significant hepatic dysfunction) was performed. All patients completed 24-hour continuous hemodiafiltration against both lactate-buffered and lactate-free dialysate. Arterial pH, blood gases, bicarbonate, and lactate, venous sodium, blood pressure, and inotrope requirements were measured before and at six hourly intervals during the first 24 hours of dialysis against each dialysate. RESULTS: CONCLUSIONS: Over the time scale of 24 hours, lactate derived from continuous dialysis circuits is efficiently cleared from the blood of most patients with multi-organ failure, but with less effect on systemic acidosis than is produced by equivalent amounts of bicarbonate.
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Authors | A G McLean, A Davenport, D Cox, P Sweny |
Journal | Kidney international
(Kidney Int)
Vol. 58
Issue 4
Pg. 1765-72
(Oct 2000)
ISSN: 0085-2538 [Print] United States |
PMID | 11012911
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Chemical References |
- Bicarbonates
- Buffers
- Hemodialysis Solutions
- Lactates
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Topics |
- APACHE
- Acid-Base Equilibrium
- Acidosis
(therapy)
- Acute Kidney Injury
(therapy)
- Adult
- Bicarbonates
(administration & dosage)
- Blood Pressure
- Buffers
- Cohort Studies
- Cross-Over Studies
- Hemodialysis Solutions
(administration & dosage)
- Hemofiltration
- Humans
- Lactates
(administration & dosage, blood)
- Liver Diseases
(therapy)
- Middle Aged
- Multiple Organ Failure
(mortality, therapy)
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