Serum alhpa 1-acid glycoprotein concentrations in healthy and tumor-bearing cats.

The purpose of this study was to evaluate alpha 1-acid glycoprotein (AGP) concentrations in tumor-bearing and healthy cats. The hypothesis of the present study was that AGP concentrations would be significantly increased in tumor-bearing cats. Serum from 51 healthy and 97 tumor-bearing, client-owned cats was harvested at the time of presentation and stored at -80 degrees C until assayed. Cats with measurable, histologically confirmed malignancies, and healthy cats of similar ages were included. Serum was assayed for AGP concentration by using a radial immunodiffusion method. AGP concentrations were significantly (P = .0051) higher in tumor-bearing (763 +/- 595 microg/mL; mean +/- SD) when compared to healthy cats (501 +/- 377 microg/mL; mean +/- SD). Of the tumor-bearing cats, 35 had carcinomas, 33 had sarcomas, and 26 had discrete, round cell tumors. AGP concentrations were 645 +/- 62 microg/mL, 660 +/- 540 microg/mL, and 967 +/- 860 microg/mL, respectively, and there were no significant differences among the groups.
AuthorsK A Selting, G K Ogilvie, S E Lana, M J Fettman, K L Mitchener, R A Hansen, K L Richardson, J A Walton, M A Scherk
JournalJournal of veterinary internal medicine / American College of Veterinary Internal Medicine (J Vet Intern Med) 2000 Sep-Oct Vol. 14 Issue 5 Pg. 503-6 ISSN: 0891-6640 [Print] UNITED STATES
PMID11012113 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Orosomucoid
  • Animals
  • Carcinoma (blood, pathology, veterinary)
  • Carcinoma, Small Cell (blood, pathology, veterinary)
  • Cat Diseases (blood, pathology)
  • Cats (blood)
  • Immunodiffusion (veterinary)
  • Orosomucoid (analysis)
  • Regression Analysis
  • Sarcoma (blood, pathology, veterinary)

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