Effects of milrinone on platelet aggregation in swine with pulmonary hypertension.

Abstract

PURPOSE:

The purpose of this study was to investigate whether the effect of milrinone on platelet aggregation was related to the selectivity of vasodilation vasculature in a swine model with PH.

MATERIALS AND METHODS:

To induce pulmonary hypertension, we injected two sets of acid-washed glass beads in 15 swine, which were divided into two groups (those receiving milrinone or not) and compared with each other.

RESULTS:

The induction of pulmonary hypertension decreased the platelet count and increased the plasma levels of thromboxane B2 and 6-keto-prostaglandin F1alpha.

CONCLUSION:

A locally high concentration of prostaglandin I2, at least in part, may produce selectivity of vasodilation in the pulmonary vasculature.

• Authors: H Tanaka, K Tajimi, Y Miyajima, M Kazama, K Kobayashi
• Journal: Journal of critical care (J Crit Care) Vol. 15 Issue 3 Pg. 113-8 (Sep 2000) ISSN: 0883-9441 [Print] United States
• PMID: 11011824 (Publication Type: Journal Article)

Chemical References

• Platelet Aggregation Inhibitors
• Thromboxane B2
• 6-Ketoprostaglandin F1 alpha
• Milrinone

Topics

• 6-Ketoprostaglandin F1 alpha (blood)
• Animals
• Biological Availability
• Blood Gas Analysis
• Hemodynamics
• Hypertension, Pulmonary (drug therapy, physiopathology)
• Male
• Milrinone (pharmacology)
• Platelet Aggregation (drug effects)
• Platelet Aggregation Inhibitors (pharmacology)
• Structure-Activity Relationship
• Swine
• Thromboxane B2 (blood)
• Vasodilation (drug effects)