Vascular osteomuscular autograft prefabrication using coral, type I collagen and recombinant human bone morphogenetic protein-2.

Abstract	In 20 male Sprague-Dawley rats, 10 pieces of L-shaped coral combined with type I collagen and recombinant human bone morphogenetic protein-2 (rhBMP-2) and 10 discs (diameter 5 mm) were wrapped in the gracilis muscle, and left pedicled on the femoral vessels. Untreated coral was buried in muscle at a distant control site in 4 animals. After 3 weeks, autografts were examined for the shape of new bone, vascular patency, and induction of bone. In all grafts in viable tissue, heterotopic bone was formed. The shape of the new bone was the same as that of the coral, and there was no significant inflammatory reaction. Part of the coral in the composite was absorbed. Bone was not formed in any of the control sites. Coral and type 1 collagen are effective as a carrier for BMP to prefabricate vascular osteomuscular autografts with designed shape. There is a potential clinical application for BMP to bioengineer microvascular free flaps with intrinsic skeletal muscle for maxillofacial reconstruction.
Authors	Q Ma, T Mao, B Liu, J Zhao, F Chen, H Wang, M Zhao
Journal	The British journal of oral & maxillofacial surgery (Br J Oral Maxillofac Surg) Vol. 38 Issue 5 Pg. 561-4 (Oct 2000) ISSN: 0266-4356 [Print] Scotland
PMID	11010796 (Publication Type: Comparative Study, Journal Article)
Copyright	Copyright 2000 The British Association of Oral and Maxillofacial Surgeons.
Chemical References	BMP2 protein, human Bmp2 protein, rat Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins Drug Carriers Recombinant Proteins Transforming Growth Factor beta recombinant human bone morphogenetic protein-2 Collagen
Topics	Animals Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins (administration & dosage) Bone Transplantation (diagnostic imaging, methods, pathology) Cattle Cnidaria Collagen (administration & dosage) Drug Carriers Feasibility Studies Humans Male Muscle, Skeletal (blood supply, transplantation) Radiography Rats Rats, Sprague-Dawley Recombinant Proteins (administration & dosage) Time Factors Transforming Growth Factor beta (administration & dosage) Transplantation, Autologous (methods, pathology)

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