Chorioamnionitis decreased incidence of respiratory distress syndrome by elevating fetal interleukin-6 serum concentration.

Abstract

Respiratory distress syndrome (RDS) of newborns is one of the most important factors determining neonatal morbidity and mortality. The interleukin-6 (IL-6) titre in cord sera of RDS-free neonates born to mothers with histological chorioamnionitis was significantly higher than that in RDS-complicated neonates without chorioamnionitis. Maternal administration of glucocorticoid suppressed the IL-6 concentrations in the cord sera of fetuses with chorioamnionitis. The fetuses without chorioamnionitis who suffered from RDS even after maternal glucocorticoid administration showed a similar IL-6 titre to that of RDS-affected neonates without chorioamnionitis. Examination of the mechanism by which IL-6 decreased the incidence of fetal RDS revealed that H441-4, a human pulmonary adenocarcinoma cell line, stimulated with recombinant (r)-IL-6 started the synthesis of mRNA and protein of pulmonary surfactant protein (SP)-A. The present study shows that IL-6 elevation in fetuses with chorioamnionitis promotes fetal lung maturation by inducing SP-A synthesis, thereby decreasing the incidence of RDS in the preterm neonates.

• Authors: K Shimoya, T Taniguchi, N Matsuzaki, A Moriyama, Y Murata, H Kitajima, M Fujimura, M Nakayama
• Journal: Human reproduction (Oxford, England) (Hum Reprod) Vol. 15 Issue 10 Pg. 2234-40 (Oct 2000) ISSN: 0268-1161 [Print] England
• PMID: 11006206 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cytokines
• Glucocorticoids
• Interleukin-6
• Proteolipids
• Pulmonary Surfactant-Associated Protein A
• Pulmonary Surfactant-Associated Proteins
• Pulmonary Surfactants

Topics

• Cell Line
• Chorioamnionitis (drug therapy, epidemiology, metabolism)
• Cytokines (blood, pharmacology)
• Female
• Fetal Blood (metabolism)
• Glucocorticoids (therapeutic use)
• Humans
• Incidence
• Infant, Newborn
• Infant, Premature
• Interleukin-6 (blood, pharmacology)
• Pregnancy
• Proteolipids (biosynthesis, drug effects, genetics)
• Pulmonary Surfactant-Associated Protein A
• Pulmonary Surfactant-Associated Proteins
• Pulmonary Surfactants (biosynthesis, drug effects, genetics)
• Respiratory Distress Syndrome, Newborn (blood, epidemiology)