Efficacy of fluconazole and liposome entrapped fluconazole for C. albicans induced experimental mycotic endophthalmitis in rabbit eyes.

Abstract

PURPOSE:

To study the efficacy of intravitreally injected plain and liposome encapsulated fluconazole in the doses of 100 and 200 microg in Candidal endophthalmitis in rabbit eyes.

METHOD:

Endophthalmitis was induced by injecting Candida albicans (1000 CFU/0.1 ml). Seventy two hours after inoculation, plain and liposome encapsulated fluconazole (REVs) were injected. At day 16 sterility was studied using vitreous culture.

RESULTS:

In the 100 & 200 microg plain fluconazole group, vitreous sterility was seen in 62.5% and 75%, respectively. In the liposome entrapped fluconazole a culture sterility of 25% and 50% for 100 microg and 200 microg, respectively, was seen.

CONCLUSION:

Plain fluconazole in the dose of 100 and 200 microg was equally effective against Candidal endophthalmitis in rabbits, but a failure of 25-37.5% of the eyes to respond, discourages one from using fluconazole as a sole therapy. Liposome entrapped fluconazole was found to be inferior to plain fluconazole in this model.

• Authors: S K Gupta, N Dhingra, T Velpandian, J Jaiswal
• Journal: Acta ophthalmologica Scandinavica (Acta Ophthalmol Scand) Vol. 78 Issue 4 Pg. 448-50 (Aug 2000) ISSN: 1395-3907 [Print] Denmark
• PMID: 10990049 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Liposomes
• Fluconazole

Topics

• Animals
• Antifungal Agents (administration & dosage)
• Candida albicans
• Candidiasis (drug therapy, microbiology)
• Drug Delivery Systems
• Endophthalmitis (drug therapy, microbiology)
• Eye Infections, Fungal (drug therapy, microbiology)
• Female
• Fluconazole (administration & dosage)
• Injections
• Liposomes
• Male
• Rabbits
• Safety
• Vitreous Body (drug effects)