Hyperfluorescence associated with serous retinal pigment epithelial detachment on indocyanine green angiography.

Abstract

PURPOSE:

Indocyanine green angiography has been reported to improve detection and delineation of occult choroidal neovascularisation in serous pigment epithelium detachment in age-related macular degeneration. The study aims to evaluate the visual acuity results of eyes affected by serous pigment epithelium detachment in age-related macular degeneration, having had indocyanine green-directed laser photocoagulation, and to correlate them to the pattern of serous pigment epithelium detachment on indocyanine green angiography.

METHODS:

Thirty-four eyes of 31 patients affected by serous pigment epithelium detachment in age-related macular degeneration were prospectively considered. Each patient underwent an ophthalmological examination including fluorescein and indocyanine green angiography one day before, and 6 weeks, 3 months, 6 months, 9 months, 12 months and 24 months after krypton-laser treatment. The serous pigment epithelium detachment was classified in the late-phases angiograms as either hypofluorescent, isofluorescent or hyperfluorescent comparing the fluorescence of the serous pigment epithelium detachment with the choroidal background fluorescence.

RESULTS:

The indocyanine green-guided laser treatment was associated with a temporary stabilization and a long-term progressive reduction of visual acuity: after 24 months visual acuity improved in 2.9%, stabilized in 26.5% and worsened in 70.5% of cases. Serous pigment epithelium detachment presenting a pretreatment hyperfluorescence had a final visual acuity of 0.06, with subfoveal choroidal neovascularisation development in 100% of cases, whereas serous pigment epithelium detachment presenting a pretreatment hypofluorescence and isofluorescence showed a final visual acuity of 0.12, with subfoveal choroidal neovascularisation development in 43.5% of eyes, with statistically significant difference.

CONCLUSION:

Overall visual acuity decreases with time after indocyanine green-guided laser treatment of choroidal neovascularisation in serous pigment epithelium detachment, and serous pigment epithelium detachment becoming hyperfluorescent in the late-phases of indocyanine green angiography has the worst functional outcome.

• Authors: M B Parodi, S Saviano, E Bondel, P Panetta, D Iustulin, S Fachin, G Ravalico
• Journal: Acta ophthalmologica Scandinavica (Acta Ophthalmol Scand) Vol. 78 Issue 4 Pg. 443-7 (Aug 2000) ISSN: 1395-3907 [Print] Denmark
• PMID: 10990048 (Publication Type: Journal Article)

Chemical References

• Indocyanine Green

Topics

• Aged
• Aged, 80 and over
• Choroidal Neovascularization (diagnosis, etiology, surgery)
• Fluorescein Angiography
• Fluorescence
• Humans
• Indocyanine Green
• Laser Coagulation
• Macular Degeneration (complications, diagnosis, surgery)
• Middle Aged
• Pigment Epithelium of Eye (pathology)
• Prospective Studies
• Retinal Detachment (diagnosis, etiology, surgery)
• Visual Acuity