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Cutaneous larva migrans in travelers: a prospective study, with assessment of therapy with ivermectin.

Abstract
The purpose of this prospective study was to update epidemiological data on cutaneous larva migrans (CLM) and to assess the therapeutic efficacy of ivermectin. We performed the study between June 1994 and December 1998 at our travel clinic. Ivermectin (a single dose of 200 microg/kg) was offered to all the patients with CLM, and its efficacy and tolerability were assessed by a questionnaire. Sixty-four patients were enrolled. All were European and had stayed in tropical areas. After the patients had returned from their destinations, 55% had lesions occur within a mean of 16 days (range, 1-120 days; >1 month in 7 patients). The initial diagnosis was wrong in 55% of patients. The mean number of lesions was 3 (range, 1-15), and the main sites were the feet (48%) and buttocks (23%). The cure rate after a single dose of ivermectin was 77%. In 14 patients, 1 or 2 supplementary doses were necessary, and the overall cure rate was 97%. The median time required for pruritus and lesions to disappear was 3 and 7 days, respectively. No systemic adverse effects were reported. Physicians' knowledge of CLM, which can have a long incubation period, is poor. Single-dose ivermectin therapy appears to be effective and well tolerated, even if several treatments are sometimes necessary.
AuthorsO Bouchaud, S Houzé, R Schiemann, R Durand, P Ralaimazava, C Ruggeri, J P Coulaud
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 31 Issue 2 Pg. 493-8 (Aug 2000) ISSN: 1058-4838 [Print] United States
PMID10987711 (Publication Type: Journal Article)
Chemical References
  • Antinematodal Agents
  • Ivermectin
Topics
  • Adolescent
  • Adult
  • Aged
  • Ancylostomiasis (drug therapy, epidemiology, parasitology)
  • Animals
  • Antinematodal Agents (therapeutic use)
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Ivermectin (therapeutic use)
  • Larva Migrans (drug therapy, epidemiology, parasitology)
  • Male
  • Middle Aged
  • Prospective Studies
  • Surveys and Questionnaires
  • Travel

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