Abstract | OBJECTIVES: BACKGROUND: METHODS: Flow-mediated vasodilation after release of 1, 3 and 5 min of transient arterial occlusion was measured in the brachial artery with high resolution two-dimensional ultrasound imaging in 48 patients with chronic heart failure before and 1 h after randomized, double-blind assignment to a single oral dose of sildenafil 12.5, 25 or 50 mg or matching placebo. RESULTS: In response to oral administration of a single dose of study drug, the change in flow-mediated vasodilation after release of 1, 3 and 5 min of arterial occlusion was significantly greater in patients receiving sildenafil 25 mg (3.3 +/- 1.9, 3.8 +/- 1.8 and 4.0 +/- 1.8%, respectively, p < 0.05) and patients receiving sildenafil 50 mg (3.7 +/- 1.3, 4.1 +/- 1.1, 3.9 +/- 1.3%, respectively, p < 0.05) than that of patients receiving placebo (0.7 +/- 1.1, 0.2 +/- 1.2, 0.6 +/- 0.8%, respectively). CONCLUSIONS:
|
Authors | S D Katz, K Balidemaj, S Homma, H Wu, J Wang, S Maybaum |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 36
Issue 3
Pg. 845-51
(Sep 2000)
ISSN: 0735-1097 [Print] United States |
PMID | 10987609
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Isoenzymes
- Phosphodiesterase Inhibitors
- Piperazines
- Purines
- Sulfones
- Sildenafil Citrate
- Phosphoric Diester Hydrolases
|
Topics |
- Blood Circulation
- Blood Flow Velocity
(drug effects)
- Cardiac Output, Low
(drug therapy, physiopathology)
- Chronic Disease
- Double-Blind Method
- Female
- Humans
- Isoenzymes
(metabolism)
- Male
- Middle Aged
- Phosphodiesterase Inhibitors
(adverse effects, therapeutic use)
- Phosphoric Diester Hydrolases
(metabolism)
- Piperazines
(adverse effects, therapeutic use)
- Purines
- Reference Values
- Sildenafil Citrate
- Sulfones
- Vasodilation
(drug effects)
|