Role of angiogenesis in benign, premalignant and malignant vulvar lesions.

Abstract

OBJECTIVE:

To investigate the presence of angiogenic factors in benign, premalignant and malignant vulvar lesions.

STUDY DESIGN:

Immunohistochemical demonstration of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) in normal vulvar skin, lichen sclerosus, vulvar intraepithelial neoplasia (VIN) and vulvar cancer.

RESULTS:

VEGF was found in the majority of vulvar cancers but only a minority of VIN lesions. PD-ECGF was found in the majority of lesions.

CONCLUSION:

Demonstration of angiogenesis may suggest which preinvasive lesions will progress to invasive cancer.

• Authors: A B MacLean, W M Reid, K J Rolfe, S J Gammell, H E Pugh, K C Gatter, A C Wong Te Fong, J C Crow, C W Perrett
• Journal: The Journal of reproductive medicine (J Reprod Med) Vol. 45 Issue 8 Pg. 609-12 (Aug 2000) ISSN: 0024-7758 [Print] United States
• PMID: 10986676 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Endothelial Growth Factors
• Lymphokines
• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factors
• Thymidine Phosphorylase

Topics

• Carcinoma in Situ (metabolism, pathology)
• Endothelial Growth Factors (metabolism)
• Female
• Humans
• Immunohistochemistry
• Lichen Sclerosus et Atrophicus (metabolism, pathology)
• Lymphokines (metabolism)
• Neovascularization, Pathologic
• Precancerous Conditions (metabolism, pathology)
• Thymidine Phosphorylase (metabolism)
• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factors
• Vulvar Diseases (metabolism, pathology)
• Vulvar Neoplasms (metabolism, pathology)