Neurotransmitter changes in the pathophysiology of Lesch-Nyhan syndrome.

Abstract

The neurological symptoms of Lesch-Nyhan syndrome (LNS) are assumed to result from the neurotransmitter changes in this disorder. Among them, the dopaminergic system is believed to play a role in the self-injurious behavior through receptor supersensitivity. However, the precise mechanism underlying the dopamine supersensitivity remains unclear. An increased serotonergic action in the striatum may be crucial for the appearance of self-injurious behavior, and pharmacological evidence suggests the efficacy of serotonin agonists/antagonists for the treatment of the self-mutilation in LNS.

• Authors: Y Saito, S Takashima
• Journal: Brain & development (Brain Dev) Vol. 22 Suppl 1 Pg. S122-31 (Sep 2000) ISSN: 0387-7604 [Print] Netherlands
• PMID: 10984673 (Publication Type: Journal Article, Review)

Chemical References

• Neurotransmitter Agents
• Receptors, Dopamine

Topics

• Animals
• Brain (pathology, physiopathology)
• Humans
• Lesch-Nyhan Syndrome (pathology, physiopathology)
• Neurons (metabolism, pathology)
• Neurotransmitter Agents (physiology)
• Receptors, Dopamine (metabolism)
• Self Mutilation (physiopathology)
• Synapses (metabolism, pathology)