Multifocal eosinophilic granuloma of the jaw: long-term follow-up of a novel intraosseous corticoid treatment for recalcitrant lesions.

Abstract

Eosinophilic granuloma of the jaws is a rather benign and localized form of Langerhans' cell histiocytosis. Treatment is usually required in larger lesions that cause local pain and swelling and pose the risk of spontaneous fractures. There are several accepted forms of treatment, which include surgery, radiation therapy, systemic and local therapy with corticoids, and systemic chemotherapy. No studies exist that compare the effectiveness of these treatment modalities. We report a novel therapeutic regimen that uses repeated intraosseous injections of triamcinolone-1 16 alpha 21-diacetat, a synthetic corticoid, which led to a rapid, complete, and durable treatment. The patient had a multilocal eosinophilic granuloma of the mandible in which radiation therapy, systemic corticoid therapy, and systemic chemotherapy had failed.

• Authors: I M Watzke, W Millesi, C Kermer, H Gisslinger
• Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (Oral Surg Oral Med Oral Pathol Oral Radiol Endod) Vol. 90 Issue 3 Pg. 317-22 (Sep 2000) ISSN: 1079-2104 [Print] United States
• PMID: 10982953 (Publication Type: Case Reports, Journal Article)

Chemical References

• Enzyme Inhibitors
• Glucocorticoids
• Triamcinolone
• triamcinolone diacetate

Topics

• Adult
• Enzyme Inhibitors (administration & dosage)
• Eosinophilic Granuloma (diagnostic imaging, drug therapy)
• Glucocorticoids (administration & dosage)
• Humans
• Injections
• Male
• Mandible
• Mandibular Diseases (diagnostic imaging, drug therapy)
• Radiography
• Treatment Outcome
• Triamcinolone (administration & dosage, analogs & derivatives)