HTLV-I-associated myelopathy manifested after renal transplantation.

Abstract

We report a patient with HTLV-I-associated myelopathy (HAM), who developed symptoms of myelopathy 4 years after cadaveric renal transplantation. Since he was seronegative before the transplantation, it is suggested that HTLV-I infection was transmitted via renal graft transplantation. He has been treated with immunosuppressive agents such as cyclosporin A (CsA), mycophenolate mofetil (MMF), and prednisolone (PSL) to prevent graft rejection. This case suggested that these immunosuppressive agents are poorly effective in suppressing either the onset or progression of HAM/TSP.

• Authors: Y Nakatsuji, F Sugai, S Watanabe, M Kaido, K Koguchi, K Abe, S Sakoda
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 177 Issue 2 Pg. 154-6 (Aug 15 2000) ISSN: 0022-510X [Print] Netherlands
• PMID: 10980313 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents

Topics

• Humans
• Immunosuppressive Agents (adverse effects)
• Kidney Failure, Chronic (surgery)
• Kidney Transplantation (adverse effects)
• Male
• Middle Aged
• Paraparesis, Tropical Spastic (pathology, transmission)