Abstract | BACKGROUND: In simultaneous pancreas- kidney transplantation, with both organs coming from the same donor, the addition of a pancreas to the kidney transplant does not jeopardize the kidney allograft outcome despite higher postoperative SPK morbidity. Pancreas allograft outcome has recently improved due to better organ selection and more accurate surgical techniques. OBJECTIVE: METHODS: RESULTS: All kidney allografts produced immediate urinary output following SPK. Two renal grafts had mild function impairment due to acute tubular damage but recovered after a short delay. Three patients died from myocardial infarction, cerebrovascular event and abdominal sepsis on days 1, 32 and 45 respectively (1 year patient survival 92%). An additional kidney allograft was lost due to a renal artery pseudo- aneurysm requiring nephrectomy on day 26. Nineteen patients (49%) had an early rejection of the kidney that was resistant to pulse- steroid therapy in 6. No kidney graft was lost due to rejection. Patients with acute kidney-pancreas rejection episodes suffered from severe infection, which was the main cause of morbidity with a 55% re-admission rate. Complications of the pancreas allograft included graft pancreatitis and sepsis, leading to a poor kidney outcome with sub-optimal kidney function at 1 year. Kidney graft survival at one year was 89% or 95% after censoring the data for patients who died with functioning grafts. CONCLUSIONS:
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Authors | R Nakache, A Weinbroum, H Merhav, E Kaplan, Y Kariv, W Khoury, M Gutman, J M Klausner |
Journal | The Israel Medical Association journal : IMAJ
(Isr Med Assoc J)
Vol. 2
Issue 7
Pg. 517-9
(Jul 2000)
ISSN: 1565-1088 [Print] Israel |
PMID | 10979325
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Child
- Diabetes Mellitus, Type 1
(surgery)
- Diabetic Nephropathies
(surgery)
- Female
- Humans
- Kidney Transplantation
- Male
- Middle Aged
- Pancreas Transplantation
- Retrospective Studies
- Transplantation, Homologous
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