Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome in childhood: a report of ten cases and review of the literature.

Abstract

UNLABELLED:

Chronic recurrent multifocal osteomyelitis is a rare chronic inflammatory musculoskeletal process observed in children and young adults. Recently, the acronym SAPHO syndrome (for synovitis, acne, pustulosis, hyperostosis, osteitis) was coined to emphasise the association between osteo-articular inflammations and different skin abnormalities which are aseptic and filled with neutrophils. In adults, chronic recurrent multifocal osteomyelitis is now a classical manifestation of SAPHO syndrome. Chronic skin disorders were seen in eight of ten children on follow-up at the University Children's Hospitals in Bern and Zurich and in 61 of 260 paediatric cases reported in the literature. The different skin lesions were palmoplantar pustulosis (n = 40), non-palmoplantar pustulosis (n = 6), psoriasis vulgaris (n = 16) or severe acne (n = 4). More rarely Sweet syndrome (n = 2) or pyoderma gangrenosum (n = 1) were reported.

CONCLUSION:

The synovitis, acne, pustulosis, hyperostosis, osteitis syndrome is pertinent even in paediatrics since skin involvement is frequent.

• Authors: B C Beretta-Piccoli, M J Sauvain, I Gal, A Schibler, T Saurenmann, H Kressebuch, M G Bianchetti
• Journal: European journal of pediatrics (Eur J Pediatr) Vol. 159 Issue 8 Pg. 594-601 (Aug 2000) ISSN: 0340-6199 [Print] Germany
• PMID: 10968238 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Acquired Hyperostosis Syndrome (complications, diagnosis, epidemiology)
• Adolescent
• Age Distribution
• Age of Onset
• Biopsy
• Child
• Child, Preschool
• Diagnosis, Differential
• Female
• Follow-Up Studies
• Humans
• Male
• Pain (etiology)
• Sex Distribution