[Decreased activity of 11-beta-hydroxysteroid dehydrogenase in patients with Cushing's syndrome].

Abstract

BACKGROUND:

To study 11 beta-hydroxysteroid dehydrogenase activity in Cushing's syndrome.

PATIENTS AND METHOD:

Measurements of free cortisol, cortisone, tetrahydrocortisol and tetrahydrocortisone in 24 h urine samples of patients with Cushing's syndrome and controls.

RESULTS:

The cortisol to cortisone and tetrahydrocortisol to tetrahydrocortisone relationship was significant (in controls, r = 0.70; p < 0.0001, and r = 0.75; p < 0.0001) respectively, but it was not in patients with Cushing's syndrome.

CONCLUSIONS:

11 beta-hydroxysteroid dehydrogenase activity is decreased in patients with Cushing's syndrome.

• Authors: P Stiefel, L Jiménez, J S García-Morillo, A Leal, J Villar, J Carneado
• Journal: Medicina clinica (Med Clin (Barc)) Vol. 115 Issue 3 Pg. 90-2 (Jun 17 2000) ISSN: 0025-7753 [Print] Spain
• Vernacular Title: Disminución de la actividad de la 11-beta-hidroxiesteroide deshidrogenasa en pacientes con síndrome de Cushing.
• PMID: 10965482 (Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Tetrahydrocortisone
• Tetrahydrocortisol
• Adrenocorticotropic Hormone
• Hydroxysteroid Dehydrogenases
• Cortisone
• Hydrocortisone

Topics

• Adrenocorticotropic Hormone (blood)
• Adult
• Cortisone (urine)
• Cushing Syndrome (diagnosis, enzymology, urine)
• Data Interpretation, Statistical
• Female
• Humans
• Hydrocortisone (urine)
• Hydroxysteroid Dehydrogenases (metabolism)
• Immunoradiometric Assay
• Luminescent Measurements
• Male
• Tetrahydrocortisol (urine)
• Tetrahydrocortisone (urine)