Determinants of umbilical cord arterial 8-iso-prostaglandin F2alpha concentrations.

Abstract

OBJECTIVE:

To determine the concentration of 8-isoPGF(2alpha) in cord blood as a measure of oxidative stress during labour, and to compare them with other established parameters of in vivo lipid peroxidation and with the acid-base status of the newborn.

METHOD:

Umbilical cord arterial and venous blood samples were collected from 81 singleton term deliveries for determination of 8-isoPGF(2alpha), malondialdehyde and organic hydroperoxides. In addition, metabolites derived from the oxidative metabolism of purines during hypoxia-reoxygenation and routine cord blood of oxygen saturation, pH, pO2, pCO2, HCO3 and base excess were measured.

RESULTS:

Arterial concentrations of 8-isoPGF(2alpha) were significantly higher in cases with fetal distress, tight nuchal cord (P < 0.001), the umbilical coiling index, and male sex (P < 0.05) (R2 = 0.48). No correlation was found with any parameter of acid-base status. In arterial and venous blood the concentrations of organic hydroperoxides and hypoxanthine significantly correlated with the fetal nuchal cord (P < 0.001) (R2 = 0.26 and 0.16, respectively).

CONCLUSION:

Our findings indicate that 8-isoPGF2(alpha) in cord arterial blood is a suitable parameter to quantify a possible oxidative stress in the fetus during labour. Measurements of the F2-isoprostane concentrations in cord blood at labour provide a clinically useful method to assess the perinatal outcome.

• Authors: Y Qin, C C Wang, H Kuhn, J Rathmann, C P Pang, M S Rogers
• Journal: BJOG : an international journal of obstetrics and gynaecology (BJOG) Vol. 107 Issue 8 Pg. 973-81 (Aug 2000) ISSN: 1470-0328 [Print] England
• PMID: 10955428 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• F2-Isoprostanes
• Purines
• 8-epi-prostaglandin F2alpha
• Malondialdehyde
• Dinoprost

Topics

• Acid-Base Imbalance (metabolism)
• Adolescent
• Adult
• Biomarkers (blood)
• Dinoprost (analogs & derivatives, blood)
• F2-Isoprostanes
• Female
• Fetal Blood
• Humans
• Infant, Newborn
• Lipid Peroxidation
• Male
• Malondialdehyde (blood)
• Obstetric Labor Complications (diagnosis)
• Oxidative Stress
• Pregnancy
• Purines (blood)
• Umbilical Arteries (metabolism)
• Umbilical Veins (metabolism)