[Nitrofurans: a modern treatment for uncomplicated urinary infections?].

Abstract

From January 1995 to December 1998, 2,912 strains of enteric bacilli were isolated from the urinary tract. Increasing antibiotic resistance in Enterobacteriaceae as a cause of urinary tract infection (UTI) led us to reevaluate first- and second-line therapies. We studied antimicrobial susceptibilities of these strains to norfloxacin (NOR), nalidixic acid (NAL), trimethoprim sulfamethoxazole (TS) and nitrofurantoin (FT) using the disk diffusion method. These results show no significant superiority of the activity of nitrofurantoin against Enterobacteriaceae compared with the other antibiotics with sustained concentration in urine. However, if we consider only multiresistant Enterobacteriaceae (cefotaxime resistant), this molecule appears to be very active. These results show a significant superiority of nitrofurantoin in vitro against these multiresistant Enterobacteriaceae. Thus, this molecule could once again become a good choice for the treatment of uncomplicated UTI.

• Authors: P Cahen, P Honderlick
• Journal: Pathologie-biologie (Pathol Biol (Paris)) Vol. 48 Issue 5 Pg. 470-1 (Jun 2000) ISSN: 0369-8114 [Print] France
• Vernacular Title: Les nitrofuranes: un traitement moderne des infections urinaires non compliquées?
• PMID: 10949843 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Infective Agents, Urinary
• Nitrofurans
• Nalidixic Acid
• Nitrofurantoin
• Trimethoprim
• Norfloxacin

Topics

• Anti-Infective Agents, Urinary (pharmacology, therapeutic use)
• Bacterial Infections (drug therapy, microbiology)
• Drug Resistance, Microbial
• Enterobacteriaceae (drug effects)
• Humans
• Microbial Sensitivity Tests
• Nalidixic Acid (pharmacology, therapeutic use)
• Nitrofurans (therapeutic use)
• Nitrofurantoin (pharmacology, therapeutic use)
• Norfloxacin (pharmacology, therapeutic use)
• Trimethoprim (pharmacology, therapeutic use)
• Urinary Tract Infections (drug therapy, microbiology)