Abstract | BACKGROUND: METHODS: RESULTS: The mean (+/-SE) 48-hour stool output was 92+/-12 g per kilogram in the racecadotril group and 170+/-15 g per kilogram in the placebo group (P<0.001), a 46 percent reduction with racecadotril. The results were similar among the 73 boys with rotavirus infections. The total stool output was 157+/-27 g per kilogram in the racecadotril group and 331+/-39 g per kilogram in the placebo group (P<0.001). The median duration of diarrhea was significantly less (P<0.001) in the racecadotril group (28 hours regardless of rotavirus status) than in the placebo group (72 and 52 hours, respectively, for rotavirus-positive and rotavirus-negative patients). The intake of oral rehydration solution was significantly lower in the racecadotril group than in the placebo group (P<0.001). Racecadotril was well tolerated; only seven patients taking racecadotril had adverse effects, which were all mild and transient. CONCLUSIONS:
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Authors | E Salazar-Lindo, J Santisteban-Ponce, E Chea-Woo, M Gutierrez |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 343
Issue 7
Pg. 463-7
(Aug 17 2000)
ISSN: 0028-4793 [Print] United States |
PMID | 10944563
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antidiarrheals
- racecadotril
- Thiorphan
- Neprilysin
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Topics |
- Acute Disease
- Antidiarrheals
(therapeutic use)
- Child, Preschool
- Combined Modality Therapy
- Developing Countries
- Diarrhea
(drug therapy, therapy)
- Double-Blind Method
- Feces
(microbiology, virology)
- Fluid Therapy
- Hospitalization
- Humans
- Infant
- Male
- Neprilysin
(antagonists & inhibitors)
- Rotavirus
(isolation & purification)
- Thiorphan
(analogs & derivatives, therapeutic use)
- Time Factors
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