Abstract |
The prognosis of immunoblastic lymphadenopathy (IBL)-like T-cell lymphoma is grave, and its effective treatments have not been established. We applied oral cyclosporin A (CsA) treatment to two cases of IBL-like T-cell lymphoma, and succeeded in achieving complete remissions. CsA is known to have a suppressive effect on the immune system, most notably T-cells, but it also has a direct cytotoxic/apoptosis-inducing effect on lymphocytes. Its combined effects on neoplastic T-cells might have played an important role in achieving remission. In both cases, serum levels of interleukin-12 (IL-12) and tumor necrosis factor-alpha ( TNF-alpha) were elevated and decreased or returned to normal after achieving remissions. Considering that both cytokines represent monokines, it seems that a macrophage system is also involved in the pathogenesis of this disorder. Our two cases indicate that administration of CsA may be an effective therapy for IBL-like T-cell lymphoma.
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Authors | N Takemori, J Kodaira, T Sato, H Sakurai, N Akakura, S Kimura, M Katagiri |
Journal | Human cell
(Hum Cell)
Vol. 13
Issue 1
Pg. 35-42
(Mar 2000)
ISSN: 0914-7470 [Print] Japan |
PMID | 10937345
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Cytokines
- Immunosuppressive Agents
- Cyclosporine
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Topics |
- Administration, Oral
- Aged
- Cyclosporine
(administration & dosage)
- Cytokines
(blood)
- Female
- Humans
- Immunoblastic Lymphadenopathy
(drug therapy, immunology)
- Immunosuppressive Agents
(administration & dosage)
- Lymphoma, T-Cell
(drug therapy, immunology)
- Male
- Middle Aged
- Remission Induction
- Treatment Outcome
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