Abstract | PURPOSE: METHODS: 47 patients received LTG either because of insufficient seizure control (n = 35) or serious side effects of prior antiepileptic drugs (AED). Long-term video-EEG recordings were performed before and after the introduction of LTG. The mean follow-up time was 25.5 months. RESULTS: Of 12 patients with refractory childhood absence epilepsy, 9 became seizure free; in one child with absences with eyelid myoclonia, absence frequency was reduced > 50%; in 2 children with absences with a mild atonic component, seizure reduction was only transient. Of 12 patients with juvenile absence epilepsy, 10 became seizure-free and, in 2, a > 50% reduction was obtained. In 15 patients with juvenile myoclonic epilepsy, complete seizure control was achieved in 7 patients, in 6 patients myoclonia persisted. In one patient generalized tonic-clonic seizures also persisted and another patient developed a rash, LTG was therefore stopped. Of 5 patients with grand-mal on awakening, 3 became seizure-free, and a reduction of > 50% was obtained in one patient; LTG was stopped in one patient because of poor compliance. Three patients with pure photosensitive epilepsy became seizure-free. At the end of the study, 11 patients were seizure-free on LTG monotherapy, and in most other patients concomitant AED dosage could be substantially reduced. CONCLUSIONS:
Lamotrigine was effective and well tolerated in patients with various IGE syndromes, although differences were observed between individual syndromes and seizure types.
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Authors | C A Gericke, F Picard, A de Saint-Martin, S Strumia, C Marescaux, E Hirsch |
Journal | Epileptic disorders : international epilepsy journal with videotape
(Epileptic Disord)
Vol. 1
Issue 3
Pg. 159-65
(Sep 1999)
ISSN: 1294-9361 [Print] France |
PMID | 10937148
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticonvulsants
- Triazines
- Lamotrigine
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Topics |
- Adolescent
- Adult
- Anticonvulsants
(administration & dosage, adverse effects)
- Child
- Child, Preschool
- Dose-Response Relationship, Drug
- Drug Therapy, Combination
- Electroencephalography
(drug effects)
- Epilepsies, Myoclonic
(diagnosis, drug therapy)
- Epilepsy, Absence
(diagnosis, drug therapy)
- Epilepsy, Generalized
(diagnosis, drug therapy)
- Female
- Follow-Up Studies
- Humans
- Lamotrigine
- Male
- Middle Aged
- Prospective Studies
- Treatment Outcome
- Triazines
(administration & dosage, adverse effects)
- Video Recording
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