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Autocrine and paracrine growth inhibitors of breast cancer cells.

Abstract
Breast epithelial cells produce both mitogens and growth inhibitors which are involved in the control of mammary gland development through autocrine and paracrine pathways. While the mechanisms of action of several growth factors have been well established and related strategies proposed for breast cancer therapy, little is known concerning growth inhibitors. In this review, we present an overview of current information about major autocrine and paracrine growth inhibitors of breast epithelial cells, and we discuss their potential functions in the control of breast cancer development.
AuthorsX L Bourhis, R A Toillon, B Boilly, H Hondermarck
JournalBreast cancer research and treatment (Breast Cancer Res Treat) Vol. 60 Issue 3 Pg. 251-8 (Apr 2000) ISSN: 0167-6806 [Print] NETHERLANDS
PMID10930113 (Publication Type: Journal Article, Review)
Chemical References
  • Growth Substances
  • Proteoglycans
Topics
  • Autocrine Communication (drug effects)
  • Breast Neoplasms (drug therapy, metabolism, pathology)
  • Epithelial Cells (drug effects)
  • Female
  • Growth Substances (pharmacology)
  • Humans
  • Paracrine Communication (drug effects)
  • Proteoglycans (metabolism)
  • Tumor Cells, Cultured (drug effects)

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