Abstract | OBJECTIVE: BACKGROUND: Accumulating evidence suggests that short-course (ie, < or = 5 days) antimicrobial therapy may have equivalent or superior efficacy compared with traditional longer (10- to 14-day) therapies. RESULTS: In GABHS tonsillopharyngitis, short-course therapy with 6 days of amoxicillin, 4 or 5 days of various cephalosporins, and 5 days of azithromycin (10 mg/kg once daily on all 5 days in pediatric patients) are all reasonable alternatives to traditional 10-day penicillin therapy. In uncomplicated acute ( suppurative) otitis media, single-dose intramuscular ceftriaxone or 3- to 5-day short-course oral antimicrobial therapy should be effective in > or = 80% of patients. However, more research is needed in children aged <2 years, since short-course therapy may not be successful in most patients in this population. In sinusitis, most short-course therapy data have involved acute maxillary disease in adult patients. Preliminary results are encouraging, but more study is needed, especially in children. CONCLUSIONS:
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Authors | D R Guay |
Journal | Clinical therapeutics
(Clin Ther)
Vol. 22
Issue 6
Pg. 673-84
(Jun 2000)
ISSN: 0149-2918 [Print] United States |
PMID | 10929916
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Adult
- Anti-Infective Agents
(therapeutic use)
- Humans
- Respiratory Tract Infections
(drug therapy, microbiology)
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