Abstract | OBJECTIVE: METHODS: A novel radiosurgery system was developed at the University of Michigan Medical Center with a standard multileaf collimator and a computer-controlled radiotherapy system. Data were accumulated prospectively on all patients undergoing treatment with this system since treatment began in 1995. RESULTS: Thirty-six patients with 37 AVMs have undergone treatment to date. At more than 3 years since treatment, 15 of 16 AVMs with a volume of less than 10 cc were proven to be obliterated by angiography or magnetic resonance imaging, and one was considered a treatment failure. At more than 24 months since therapy, all four AVMs with a volume of 10 to 25 cc were obliterated. Four patients with AVMs with a volume of more than 25 cc have undergone staged therapy, treating the entire volume to 10 Gy twice, but none has been followed long enough to demonstrate a final outcome. There were four transient and no permanent complications. CONCLUSION: Our early data indicate that stereotactic radiosurgery of cerebral AVMs with a linear accelerator and a multileaf collimator is safe and effective. Large AVMs may be especially suitable for this mode of therapy. Staged treatment of very large AVMs seems to be a promising addition to standard treatment, but longer follow-up is necessary to confirm that complete obliteration can be achieved.
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Authors | D A Ross, H M Sandler, J M Balter, J A Hayman, J Deveikis, D L Auer |
Journal | Neurosurgery
(Neurosurgery)
Vol. 47
Issue 1
Pg. 123-8; discussion 128-30
(Jul 2000)
ISSN: 0148-396X [Print] United States |
PMID | 10917355
(Publication Type: Clinical Trial, Journal Article)
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Topics |
- Adolescent
- Adult
- Aged
- Child
- Humans
- Intracranial Arteriovenous Malformations
(surgery)
- Middle Aged
- Prospective Studies
- Radiosurgery
(instrumentation)
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