Abstract | BACKGROUND: METHODS: RESULTS: Distributions of ANP and PNE levels at baseline in patients with heart failure of ischemic and nonischemic causes were virtually identical. ANP levels at baseline were inversely related to LVEF (r = -0.39; P = .0001), exercise duration (r = -0.19; P = .0001), and peak oxygen consumption (r = -0.27; P = .008) and directly related to LV (r = 0.23; P = .0006) and right ventricular dilatation (r = 0.23; P = .0008). The increase in ANP levels between baseline and 3 months (P = .02) and 1 year (P = .03) was significantly less in the felodipine-ER group than in the placebo group, but PNE levels did not differ between treatment groups. Hospital-free survival was directly related to baseline ANP (P = .0002) and PNE levels (P = .004). All-cause mortality was related to baseline PNE levels (P = .02) but not baseline ANP levels. CONCLUSION:
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Authors | R F Smith, T Germanson, D Judd, M Wong, S Ziesche, I S Anand, W R Taylor, J N Cohn |
Journal | Journal of cardiac failure
(J Card Fail)
Vol. 6
Issue 2
Pg. 97-107
(Jun 2000)
ISSN: 1071-9164 [Print] United States |
PMID | 10908083
(Publication Type: Clinical Trial, Clinical Trial, Phase III, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Biomarkers
- Vasodilator Agents
- Atrial Natriuretic Factor
- Felodipine
- Norepinephrine
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Topics |
- Administration, Oral
- Adolescent
- Atrial Natriuretic Factor
(blood)
- Biomarkers
(blood)
- Cause of Death
- Felodipine
(administration & dosage)
- Heart Failure
(blood, drug therapy, mortality, physiopathology)
- Humans
- Male
- Norepinephrine
(blood)
- Radioimmunoassay
- Stroke Volume
- Survival Rate
- United States
(epidemiology)
- Vasodilator Agents
(administration & dosage)
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