Erythematous plaques due to platelet plugging: a clue to underlying myeloproliferative disorder.

Abstract

We report a syndrome in a middle-aged woman characterized by tender erythematous plaques with histologic evidence of dramatic dermal vessel occlusion. These cutaneous findings occurred in association with progressive inferior vena cava and portal vein thrombosis while on coumarin anticoagulation, following hepatic transplantation for Budd-Chiari syndrome. The material occluding dermal vessels was proven by immunohistochemical staining to be platelet plugs. These findings led to the diagnosis of an underlying myeloproliferative disorder explaining both her cutaneous and liver abnormalities and institution of appropriate platelet directed anticoagulation with aspirin.

• Authors: M S Stone, K J Robson, W W Piette
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 43 Issue 2 Pt 2 Pg. 355-7 (Aug 2000) ISSN: 0190-9622 [Print] United States
• PMID: 10901722 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Bone Marrow (pathology)
• Budd-Chiari Syndrome (diagnosis, pathology)
• Capillaries (pathology)
• Facial Dermatoses (diagnosis, pathology)
• Female
• Humans
• Middle Aged
• Myeloproliferative Disorders (diagnosis, pathology)
• Paraneoplastic Syndromes (diagnosis, pathology)
• Platelet Aggregation (physiology)
• Skin (blood supply, pathology)
• Skin Diseases, Vascular (diagnosis, pathology)
• Thrombophilia (diagnosis, pathology)