A case with acute renal failure complicated by Waldenström's macroglobulinemia and cryoglobulinemia.

Abstract

We encountered a 53-year-old man associated with acute renal failure caused by Waldenström's macroglobulinemia and type I cryoglobulinemia. Treatment with prednisolone and cyclophosphamide induced a rapid recovery from acute renal failure. Renal histology revealed endocapillary proliferation and lobular formation with scattered subendothelial, amorphous and periodic acid-Schiff (PAS)-positive materials in the glomerular capillaries which were positive for IgM on immunofluorescence study. Although the exact mechanism for pathophysiology of acute renal failure remains unknown, treatment with prednisolone and cyclophosphamide could induce a rapid recovery from acute renal failure accompanied by Waldenström's macroglobulinemia and type I cryoglobulinemia.

• Authors: K Yonemura, T Suzuki, K Sano, Y Fujigaki, N Ikegaya, A Hishida
• Journal: Renal failure (Ren Fail) Vol. 22 Issue 4 Pg. 511-5 ( 2000) ISSN: 0886-022X [Print] England
• PMID: 10901188 (Publication Type: Case Reports, Journal Article)

Chemical References

• Chlorambucil
• Prednisolone

Topics

• Acute Kidney Injury (diagnosis, etiology, therapy)
• Chlorambucil (therapeutic use)
• Combined Modality Therapy
• Cryoglobulinemia (complications, diagnosis, drug therapy)
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Prednisolone (therapeutic use)
• Renal Dialysis
• Waldenstrom Macroglobulinemia (complications, diagnosis, drug therapy)