[Immunomodulatory effects of intravenous immunoglobulins].

Intravenous immunoglobulin (IVIg) has been used for many years in the treatment of primary and secondary antibody deficiencies. IVIg was first demonstrated to be effective in auto-immune desorders twenty years ago in the treatment of idiopathic thrombocytopenic purpura. The beneficial effect of IVIg has since been established in the Guillain-Barré syndrome, chronic inflammatory demenilating polyneuropathy, myasthenia gravis, dermatomyositis, Kawasaki syndrome and graft versus host disease. The beneficial effect of IVIg has been suggested in a large number of other auto-immune and systemic inflammatory conditions. The mode of action of IVIg is complex, involving Fc receptor blockade, interference with complement activation and the cytokine network, provision of anti-idiotypic antibodies and modulation of T and B cell activation and differentiation. Such a broad range of activities reflects the function of normal circulating immunoglobulins in maintaining tolerance to self in healthy individuals.
AuthorsM Kazatchkine, L Mouthon, S V Kaveri
JournalAnnales de meĢdecine interne (Ann Med Interne (Paris)) Vol. 151 Suppl 1 Pg. 1S13-8 (May 2000) ISSN: 0003-410X [Print] FRANCE
Vernacular TitleEffets immunomodulateurs des immunoglobulines intraveineuses.
PMID10896983 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Adjuvants, Immunologic
  • Antibodies, Anti-Idiotypic
  • Cytokines
  • Immunoglobulins, Intravenous
  • Receptors, Fc
  • Adjuvants, Immunologic (therapeutic use)
  • Antibodies, Anti-Idiotypic (therapeutic use)
  • Autoimmune Diseases (therapy)
  • Complement Activation (immunology)
  • Cytokines (immunology)
  • Humans
  • Immunoglobulins, Intravenous (therapeutic use)
  • Immunologic Deficiency Syndromes (therapy)
  • Lymphocyte Activation (immunology)
  • Polyneuropathies (therapy)
  • Receptors, Fc (antagonists & inhibitors)

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