Abstract | PURPOSE: MATERIALS AND METHODS: Meta-analysis was chosen as the method of evaluating the literature. Study inclusion criteria were testosterone given as the only therapy for erectile dysfunction and a clearly stated definition of response for evaluating treatment success or failure. RESULTS: We evaluated 73 articles obtained by a MEDLINE search of 1966 to 1998 and included 16 in our study. The overall response rate was 57%. In the 9 series with response rate by etiology patients with primary versus secondary testicular failure had a response rate of 64% versus 44% (p <0.001). Intramuscular and oral methods of delivery were equivalent with a response rate of 51.3% and 53.2%, respectively. However, the response to transdermal therapy was significantly different from that of intramuscular and oral treatment (80.9% versus 51.3% and 53.2%, respectively, p <0.001). The mean confidence level response for testosterone treatment was 16. 7% in the placebo and 65.4% in the treated group (p <0.0001). CONCLUSIONS: Our meta-analysis of the usefulness of androgen replacement therapy for erectile dysfunction indicates that the response rate for a primary etiology was improved over that for a secondary etiology, transdermal testosterone therapy was more effective than intramuscular or oral treatment, and intramuscular and oral treatments were equivalent. In addition, there was a statistically significant difference in favor of testosterone over placebo, implying a role for supplementation in select groups.
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Authors | P Jain, A W Rademaker, K T McVary |
Journal | The Journal of urology
(J Urol)
Vol. 164
Issue 2
Pg. 371-5
(Aug 2000)
ISSN: 0022-5347 [Print] United States |
PMID | 10893588
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
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Topics |
- Administration, Oral
- Erectile Dysfunction
(drug therapy)
- Hormone Replacement Therapy
- Humans
- Injections, Intramuscular
- Male
- Testosterone
(administration & dosage)
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