Serum alpha-fetoprotein levels in Beckwith-Wiedemann syndrome.

Abstract

We conducted a retrospective study that compared serial alpha-fetoprotein (AFP) concentrations obtained from 22 children with Beckwith-Wiedemann syndrome (BWS) with levels established for healthy children. The AFP concentration is greater in patients with BWS and declines during the postnatal period at a significantly slower rate than what is reported in healthy children. AFP levels obtained in the course of routine tumor screening in children with BWS should be interpreted with a normal curve established specifically for BWS rather than with previously published data for healthy infants and children.

• Authors: D B Everman, C Shuman, B Dzolganovski, M A O'riordan, R Weksberg, N H Robin
• Journal: The Journal of pediatrics (J Pediatr) Vol. 137 Issue 1 Pg. 123-7 (Jul 2000) ISSN: 0022-3476 [Print] United States
• PMID: 10891834 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• alpha-Fetoproteins

Topics

• Beckwith-Wiedemann Syndrome (blood)
• Child, Preschool
• Female
• Humans
• Infant
• Infant, Newborn
• Male
• Retrospective Studies
• alpha-Fetoproteins (analysis)