Inhibition of azoxymethane-induced colon cancer by orange juice.

Abstract

Previous research has shown that hesperidin, a flavanone glycoside in orange juice, inhibits colon carcinogenesis and that feeding double-strength orange juice delays the onset of chemically induced mammary cancer in rats. This study determined whether feeding single-strength, pasteurized orange juice would inhibit azoxymethane (AOM)-induced colon cancer in male Fischer 344 rats. Colon cancer was initiated by injecting AOM (15 mg/kg body wt) at 22 and 29 days of age. One week after the second AOM injection, orange juice replaced drinking water for the experimental group (n = 30). The rats were killed 28 weeks later, and tumors were removed for histological analysis. Feeding orange juice reduced tumor incidence by 22% (p < 0.05). Tumor reduction was associated with a decreased labeling index and proliferation zone in the colonic mucosa. Hesperidin, other flavonoids, limonin 17-beta-D-glucopyranoside, and other limonoid glucosides are potential chemopreventive agents in orange juice that could account for the decreased colon tumorigenesis associated with feeding orange juice.

• Authors: Y Miyagi, A S Om, K M Chee, M R Bennink
• Journal: Nutrition and cancer (Nutr Cancer) Vol. 36 Issue 2 Pg. 224-9 ( 2000) ISSN: 0163-5581 [Print] United States
• PMID: 10890034 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Carcinogens
• Azoxymethane

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Azoxymethane
• Beverages
• Carcinogens
• Citrus (chemistry, therapeutic use)
• Colon (physiopathology)
• Colonic Neoplasms (chemically induced, prevention & control)
• Male
• Phytotherapy
• Rats
• Rats, Inbred F344