Abstract |
The effects of a prolylendopeptidase inhibitor, 1-[3-(2-indanylanylacetyl)-L-thioprolyl] pyrrolidine (Z-321), on lordosis behavior were investigated in estrogen and progesterone-treated ovariectomized rats. Females were orally administered 100, 200 or 300 mg/kg Z-321 or the vehicle (control). The mean lordosis quotient in the rats given 300 mg/kg Z-321 was lower than that in control group, but that in rats given 100 or 200 mg/kg Z-321 was not lower. Thus, Z-321 suppressed lordosis in estrogen and progesterone-treated ovariectomized rats. Peptide neurotransmitters, especially those containing proline, are thought to be involved in the inhibitory mechanisms for lordosis behavior.
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Authors | I Oosuka, Y Tanaka, N Miura, K Yamanouchi |
Journal | Japanese journal of pharmacology
(Jpn J Pharmacol)
Vol. 83
Issue 1
Pg. 82-5
(May 2000)
ISSN: 0021-5198 [Print] Japan |
PMID | 10887944
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 1-(3-(2-indanylacetyl)-L-thioprolyl)pyrrolidine
- Protease Inhibitors
- Pyrrolidines
- Vasopressins
- Cholecystokinin
- Serine Endopeptidases
- PREPL protein, human
- Prolyl Oligopeptidases
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Topics |
- Animals
- Cholecystokinin
(physiology)
- Female
- Motor Activity
(drug effects)
- Posture
- Prolyl Oligopeptidases
- Protease Inhibitors
(pharmacology)
- Pyrrolidines
(pharmacology)
- Rats
- Rats, Wistar
- Serine Endopeptidases
(physiology)
- Sexual Behavior, Animal
(drug effects)
- Vasopressins
(physiology)
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