[Drug-induced enterocolitis. Important differential diagnosis in the investigation of diarrhea and intestinal hemorrhage].

Abstract

This article is a review of the side-effects of drugs affecting the small and large intestines. Pseudomembranous colitis is caused by antibiotics facilitating an overgrowth of Clostridium difficile. A hemorrhagic colitis, generally self-limiting, can be caused by penicillin, amoxycillin and ampicillin. Toxicity of NSAID may induce intestinal ulcers, diaphragm-like strictures, perforation, colitis and relapse of inflammatory bowel disease. Drug-induced lymphocytic colitis has been reported due to ticlopidine, Cyclo 3 Fort, and occasionally by ranitidine, carbamazepine, vinburnine, tardyferon, and flutamide. Sulphasalazine and 5-ASA can cause relapse of ulcerative colitis. Neutropenic enterocolitis is a severe complication to cytotoxic therapy for cancer. Ischemic colitis can be caused by drugs inducing mesenteric vasoconstriction.

• Authors: C Tysk
• Journal: Lakartidningen (Lakartidningen) Vol. 97 Issue 21 Pg. 2606-10 (May 24 2000) ISSN: 0023-7205 [Print] Sweden
• Vernacular Title: Läkemedelsutlöst enterokolit. Viktig differentialdiagnos vid utredning av diarré och tarmblödning.
• PMID: 10881520 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Anti-Bacterial Agents
• Anti-Inflammatory Agents, Non-Steroidal
• Antineoplastic Agents
• Antirheumatic Agents
• Organogold Compounds
• Penicillins
• Sulfasalazine

Topics

• Anti-Bacterial Agents (adverse effects)
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• Antineoplastic Agents (adverse effects)
• Antirheumatic Agents (adverse effects)
• Colonoscopy
• Diagnosis, Differential
• Diarrhea (chemically induced)
• Enterocolitis (chemically induced, diagnosis, pathology)
• Enterocolitis, Pseudomembranous (chemically induced, diagnosis)
• Gastrointestinal Hemorrhage (chemically induced)
• Humans
• Intestinal Mucosa (blood supply, drug effects, pathology)
• Organogold Compounds
• Penicillins (adverse effects)
• Sulfasalazine (adverse effects)