Abstract | BACKGROUND: METHODS: Phase II study. We evaluated 11 children with AA or GM who had received no prior treatment. A magnetic resonance image (MRI) study of the tumor was made after surgery to evaluate residual tumor and routine laboratory analysis. Chemotherapy with carboplatin, ifosfamide and etoposide was given every 3 weeks for four courses. MRI studies were repeated after the second and last courses and laboratory analyses were carried out before each course to evaluate toxicity. Each patient then received hyperfractionated radiotherapy and a final MRI was done at the end of the treatment. RESULTS: Sixty percent of the patients had partial response, 30% complete response after two courses, and 60% of CR after four courses. Supratentorial and infratentorial tumors had a good response to chemotherapy. Brainstem tumors had an initial response after two courses and then increased in size. AA was the tumor with the greatest reduction of residual tumor after treatment. Overall and free survival at 53 months was 70%. To date, three patients have died secondary to tumoral progression. There have been no relapses in the seven patients with a CR. CONCLUSIONS: Postoperative chemotherapy with ICE reduces the tumor size and increases the survival rate of pediatric patients with malignant astrocytomas with minimal toxicity. Brainstem responded poorly to treatment.
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Authors | E López-Aguilar, A C Sepúlveda-Vildósola, H Rivera-Márquez, F Cerecedo-Díaz, I Hernández-Contreras, G Ramón-García, J Diegopérez-Ramírez, E Santacruz-Castillo |
Journal | Archives of medical research
(Arch Med Res)
2000 Mar-Apr
Vol. 31
Issue 2
Pg. 186-90
ISSN: 0188-4409 [Print] United States |
PMID | 10880725
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article)
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Chemical References |
- Etoposide
- Carboplatin
- Mesna
- Ifosfamide
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Topics |
- Adolescent
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, therapeutic use)
- Astrocytoma
(drug therapy, mortality, radiotherapy)
- Brain Neoplasms
(drug therapy, mortality, radiotherapy)
- Carboplatin
(administration & dosage)
- Child
- Child, Preschool
- Combined Modality Therapy
- Cranial Irradiation
- Disease-Free Survival
- Etoposide
(administration & dosage)
- Female
- Glioblastoma
(drug therapy, mortality, radiotherapy)
- Humans
- Ifosfamide
(administration & dosage)
- Life Tables
- Male
- Mesna
(administration & dosage)
- Premedication
- Prospective Studies
- Radiotherapy, Adjuvant
- Survival Analysis
- Survival Rate
- Treatment Outcome
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