Vasorelaxing properties of carteolol in isolated porcine ciliary arteries.

Abstract

INTRODUCTION:

Carteolol is a topical beta-blocker used in ophthalmology to decrease the intraocular pressure. This study investigates the vasoactive effect of carteolol in isolated porcine ciliary processes.

MATERIAL AND METHODS:

With a myograph system isometric force measurements, quiescent vessels or vessels either precontracted with endothelin-1 (0.03 microM) or the thromboxane A2 analog U 46619 (0.3 microM) were exposed, in cumulative manner, to increasing concentrations of carteolol (10 microM-3 mM). Vessels that had a functional endothelium were compared with vessels that had a non functional endothelium (intentionally and mechanically damaged).

RESULTS:

In quiescent vessels carteolol did not induce contractions. In contrast, in precontracted arteries, carteolol evoked marked relaxations which were endothelium-independent.

CONCLUSIONS:

In vitro, carteolol has a marked vasorelaxing effect on porcine ciliary arteries, however the clinical relevance of this observation for the care of glaucoma patients requires further evaluation.

• Authors: J Kasper, C Champion, J Flammer, I O Haefliger
• Journal: Klinische Monatsblatter fur Augenheilkunde (Klin Monbl Augenheilkd) Vol. 216 Issue 5 Pg. 318-20 (May 2000) ISSN: 0023-2165 [Print] Germany
• PMID: 10863704 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-Antagonists
• Vasodilator Agents
• Carteolol

Topics

• Adrenergic beta-Antagonists (pharmacology)
• Animals
• Carteolol (pharmacology)
• Ciliary Arteries (drug effects)
• Endothelium, Vascular (drug effects)
• In Vitro Techniques
• Intraocular Pressure (drug effects)
• Swine
• Vasodilator Agents (pharmacology)