HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The cross-link breaker, N-phenacylthiazolium bromide prevents vascular advanced glycation end-product accumulation.

AbstractAIMS/HYPOTHESIS:
Advanced glycation is postulated to have a pivotal role in mediating diabetic vascular complications. The emergence of thiazolium compounds such as N-phenacylthiazolium bromide which cleave preformed advanced glycation end products (AGEs) has allowed us to explore the effects of these agents on the vascular AGE accumulation and hypertrophy associated with diabetes.
METHODS:
Control and streptozotocin diabetic rats were selected at random for no treatment or treatment with N-phenacylthiazolium bromide (10 mg/kg intraperitoneally) and followed for 3 weeks. In a separate study, intervention with N-phenacylthiazolium bromide was delayed until after 3 weeks of diabetes and then given for 3 weeks (total of 6 weeks).
RESULTS:
Diabetes was associated with increased mesenteric vascular advanced glycation end products, as assessed by radioimmunoassay and immunohistochemistry. This increase in vascular AGE accumulation was prevented by N-phenacylthiazolium bromide treatment. Diabetes-associated mesenteric vascular hypertrophy was attenuated by treatment with N-phenacylthiazolium bromide only if given from the time of induction of diabetes.
CONCLUSION/INTERPRETATION:
Cross-link breakers seem to be effective in preventing or reversing accumulation of advanced glycation end-products in blood vessels and have the potential to play a part in the treatment of diabetic vascular complications.
AuthorsM E Cooper, V Thallas, J Forbes, E Scalbert, S Sastra, I Darby, T Soulis
JournalDiabetologia (Diabetologia) Vol. 43 Issue 5 Pg. 660-4 (May 2000) ISSN: 0012-186X [Print] Germany
PMID10855541 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Glycated Hemoglobin A
  • Glycation End Products, Advanced
  • N-phenacylthiazolium bromide
  • Thiazoles
Topics
  • Animals
  • Blood Pressure
  • Blood Vessels (chemistry, metabolism)
  • Diabetes Mellitus, Experimental (metabolism)
  • Glycated Hemoglobin (analysis)
  • Glycation End Products, Advanced (analysis, metabolism)
  • Immunohistochemistry
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Splanchnic Circulation
  • Thiazoles (administration & dosage, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: