5-Thienyltryptamine derivatives as serotonin 5-HT1B/1D receptor agonists: potential treatments for migraine.

Abstract	A series of 5-(2- or 3-thienyl)tryptamine derivatives (9) has been synthesized and shown to be potent and selective 5-HT1D versus 5-HT1B receptor agonists and, therefore, potential treatments for migraine.
Authors	C Q Meng, S Rakhit, D K Lee, R Kamboj, K L McCallum, L Mazzocco, K Dyne, A Slassi
Journal	Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 10 Issue 9 Pg. 903-5 (May 01 2000) ISSN: 0960-894X [Print] England
PMID	10853656 (Publication Type: Journal Article)
Chemical References	HTR1B protein, human Indicators and Reagents Receptor, Serotonin, 5-HT1B Receptor, Serotonin, 5-HT1D Receptors, Serotonin Serotonin Antagonists Tryptamines
Topics	Cloning, Molecular Humans Indicators and Reagents Migraine Disorders (drug therapy) Receptor, Serotonin, 5-HT1B Receptor, Serotonin, 5-HT1D Receptors, Serotonin (drug effects) Serotonin Antagonists (chemical synthesis, pharmacology) Structure-Activity Relationship Tryptamines (chemical synthesis, pharmacology)

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