Abstract | BACKGROUND: In developing countries, Isospora belli and Cyclospora cayetanensis frequently cause chronic diarrhea in HIV-infected patients. OBJECTIVE: DESIGN: Randomized, controlled trial. SETTING: HIV clinic in Port-au-Prince, Haiti. PATIENTS: 42 HIV-infected patients with chronic diarrhea due to I. belli (n = 22) or C cayetanensis (n = 20). INTERVENTIONS: Patients were randomly assigned to receive oral trimethoprim-sulfamethoxazole (160 mg or 800 mg) or ciprofloxacin (500 mg) twice daily for 7 days. Patients who responded clinically and microbiologically received prophylaxis for 10 weeks (1 tablet orally, three times per week). MEASUREMENTS: Treatment success was measured by cessation of diarrhea and negative stool examination at day 7. Prophylaxis success was measured by recurrent disease rate. RESULTS: CONCLUSIONS:
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Authors | R I Verdier, D W Fitzgerald, W D Johnson Jr, J W Pape |
Journal | Annals of internal medicine
(Ann Intern Med)
Vol. 132
Issue 11
Pg. 885-8
(Jun 06 2000)
ISSN: 0003-4819 [Print] United States |
PMID | 10836915
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anti-Infective Agents
- Ciprofloxacin
- Trimethoprim, Sulfamethoxazole Drug Combination
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Topics |
- AIDS-Related Opportunistic Infections
(drug therapy)
- Adolescent
- Adult
- Animals
- Anti-Infective Agents
(therapeutic use)
- Chronic Disease
- Ciprofloxacin
(therapeutic use)
- Coccidiosis
(drug therapy)
- Diarrhea
(drug therapy, microbiology)
- Drug Administration Schedule
- Eucoccidiida
- Humans
- Isospora
- Middle Aged
- Recurrence
- Trimethoprim, Sulfamethoxazole Drug Combination
(therapeutic use)
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