Abstract | BACKGROUND AND PURPOSE: METHODS: RESULTS: Of 65 children, 7 had a stroke in the neonatal/perinatal period and therefore were analyzed separately. Thirty-one of the remaining 58 patients with pediatric stroke (53.4%) were found to have at least 1 thrombophilia marker compared with only 25.5% of control subjects. None of the patients or control subjects had protein S or antithrombin III deficiency. The prevalence of protein C deficiency was higher among pediatric stroke patients than among control subjects, but the difference was not statistically significant (OR=7, 95% CI 0.75 to 65.1). Heterozygous FII G20210A and homozygous MTHFR 677T were not associated with an increased risk for stroke (OR=1.29, 95% CI 0.2 to 8.2; and OR=1.06, 95% CI 0.4 to 2.7, respectively). In contrast, the presence of APLA was associated with a >6-fold risk of stroke (OR=6. 08, 95% CI 1.5 to 24.3), and the heterozygosity for FVL increased the risk of stroke by almost 5-fold (OR=4.82, 95% CI 1.4 to 16.5). Five patients with pediatric stroke had a combination of > or =2 thrombophilia markers, whereas none of the control subjects had a combination of the markers. Most of the patients with neonatal/perinatal stroke were found to have at least 1 thrombophilia marker. CONCLUSIONS: These data suggest that the prevalence of thrombophilia markers is increased in children with stroke compared with control subjects and, specifically, that FVL and APLA contribute significantly to stroke occurrence.
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Authors | G Kenet, S Sadetzki, H Murad, U Martinowitz, N Rosenberg, S Gitel, G Rechavi, A Inbal |
Journal | Stroke
(Stroke)
Vol. 31
Issue 6
Pg. 1283-8
(Jun 2000)
ISSN: 0039-2499 [Print] United States |
PMID | 10835445
(Publication Type: Journal Article)
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Chemical References |
- 3' Untranslated Regions
- Antibodies, Antiphospholipid
- Biomarkers
- factor V Leiden
- Factor V
- Prothrombin
- Oxidoreductases Acting on CH-NH Group Donors
- Methylenetetrahydrofolate Reductase (NADPH2)
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Topics |
- 3' Untranslated Regions
(genetics)
- Adolescent
- Age of Onset
- Antibodies, Antiphospholipid
(analysis)
- Antiphospholipid Syndrome
(complications, epidemiology, immunology)
- Autoimmune Diseases
(complications, epidemiology, immunology)
- Biomarkers
- Brain Ischemia
(epidemiology, etiology, genetics, immunology)
- Child
- Child, Preschool
- Comorbidity
- Ethnicity
(genetics)
- Factor V
(genetics)
- Factor V Deficiency
(complications, epidemiology, genetics)
- Female
- Genetic Predisposition to Disease
- Humans
- Infant
- Infant, Newborn
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Odds Ratio
- Oxidoreductases Acting on CH-NH Group Donors
(deficiency, genetics)
- Point Mutation
- Polymorphism, Genetic
- Protein C Deficiency
(complications, epidemiology, genetics)
- Prothrombin
(genetics)
- Risk Factors
- Thrombophilia
(complications, epidemiology, genetics, immunology)
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