Thioperamide, a selective histamine H3 receptor antagonist, protects against PTZ-induced seizures in mice.

Abstract

The effect of selective histamine H3-receptor antagonist thioperamide was studied on PTZ-induced seizures in mice. Thioperamide significantly protected clonic seizures induced by PTZ in a dose-dependent manner. The effect of thioperamide was completely countered by pretreatment with R (alpha)-methylhistamine (RAMH), a selective H3-receptor agonist suggesting that the observed effect of thioperamide was elicited by histamine H3-receptors. RAMH alone did not significantly modify PTZ seizures. The findings are consistent with a role for the histaminergic neuronal system in seizures and suggest that H3-receptors may play an important role in modulating clonic seizures induced by PTZ in mice.

• Authors: D Vohora, S N Pal, K K Pillai
• Journal: Life sciences (Life Sci) Vol. 66 Issue 22 Pg. PL297-301 (Apr 21 2000) ISSN: 0024-3205 [Print] Netherlands
• PMID: 10834305 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Histamine Antagonists
• Methylhistamines
• Piperidines
• Protective Agents
• Receptors, Histamine H3
• alpha-methylhistamine
• thioperamide
• Pentylenetetrazole

Topics

• Animals
• Dose-Response Relationship, Drug
• Histamine Antagonists (pharmacology, therapeutic use)
• Male
• Methylhistamines (pharmacology)
• Mice
• Pentylenetetrazole
• Piperidines (pharmacology, therapeutic use)
• Protective Agents (pharmacology, therapeutic use)
• Receptors, Histamine H3 (drug effects, metabolism)
• Seizures (chemically induced, prevention & control)